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When we try to explain the dynamic relationship between actors and their environment, “unidirectional” paradigms clustered at either end of an agency–determinism continuum, theoretical absolutes, and a focus on final outcomes are of limited value. Comparative research is uniquely positioned to move beyond such limitations and toward accounts of organizing that incorporate variation, interests, and interaction. To guide comparative research toward this more relational approach, we (1) highlight a move toward the middle ground of the agency–determinism continuum, that is, varieties of interaction and mutual influence between actors and their environments across levels of analysis; and (2) propose to conceptualize actor–environment relations as a “negotiation.” We use this metaphorical lens to stimulate a focus on the variety of different “negotiation spaces” and “negotiation moves,” which actors may utilize in an organizational field to affect stability or change. We provide an exemplary application of the framework and conclude with some observation on the implications for future research.